Artigos

Follow up of a robust meta-signature to identify Zika virus infection in Aedes aegypti: another brick in the wall

30 de Maio de 2018

The mosquito Aedes aegypti is the main vector of several arthropod-borne diseases that have global impacts. In a previous meta-analysis, our group identified a vector gene set containing 110 genes strongly associated with infections of dengue, West Nile and yellow fever viruses. Of these 110 genes, four genes allowed a highly accurate classification of infected […]

Association between expansion of primary healthcare and racial inequalities in mortality amenable to primary care in Brazil: A national longitudinal analysis

21 de Março de 2018

Universal health coverage (UHC) can play an important role in achieving Sustainable Development (SDG) 10, which addresses reducing inequalities, but little supporting evidence available from low- and middle-income countries. Brazil’s Estratégia de Saúde da Família (ESF) (family health strategy) is a community-based primary healthcare (PHC) programme that has been expanding since the 1990s and is […]

Large Reductions In Amenable Mortality Associated With Brazil’s Primary Care Expansion And Strong Health Governance

Strong health governance is key to universal health coverage. However, the relationship between governance and health system performance is underexplored. We investigated whether expansion of the Brazilian Estratégia de Saúde da Família (ESF; family health strategy), a community-based primary care program, reduced amenable mortality (mortality avoidable with timely and effective health care) and whether this […]

Meta-analysis of Aedes aegypti expression Datasets: comparing Virus infection and Blood-Fed Transcriptomes to identify Markers of Virus Presence

Challenges in administrative data linkage for research

Linkage of population-based administrative data is a valuable tool for combining detailed individual-level information from different sources for research. While not a substitute for classical studies based on primary data collection, analyses of linked administrative data can answer questions that require large sample sizes or detailed data on hard-to-reach populations, and generate evidence with a […]

Probabilistic integration of large Brazilian socioeconomic and clinical databases

On the Accuracy and Scalability of Probabilistic Data Linkage Over the Brazilian 114 Million Cohort

16 de Março de 2018