Why was the cohort set up?
The CIDACS (Centre for Data and Knowledge Integration for Health) Birth Cohort is a Brazilian population-based cohort derived from linked data, developed to investigate the relationships between prenatal and early life events on health-related outcomes for infants, children, adolescents and mothers in the context of social inequalities. Societal determinants influence the health and well-being of the mother, the intrauterine environment and the fetal development before birth, increasing the risk of fetal loss as well as low birthweight and prematurity.1,2 Adverse birth outcomes, such as low birthweight, not only affect mortality and development during the early years, but also educational attainment, economic participation and long-term health outcomes.3–6 There is clear evidence that disruption (either biological or social) in the intrauterine life and/or during the first years of life can have significant consequences for health in adulthood, increasing the risk of diseases such as cardiovascular diseases, diabetes, psychiatric illness and even some cancers. Besides, lack of access to or poor quality of prenatal care has been associated with congenital malformations and rare late complications such as autoimmune diseases, diabetes and mental disorders.7–15
The design of CIDACS Birth Cohort follows a life course perspective, using routinely collected data from Brazil. The overall objective is to research the effect of obstetric and prenatal conditions, congenital infections and other potential social and environmental determinants and the impact of social policies on birth, growth, morbidity and survival, overall and in subgroups of interest in a dynamic Brazilian birth cohort. The use of large, routinely collected, high-quality social and health databases provides a unique opportunity to examine factors that might result in long-term and rare child and mother outcomes over time without the limitations of a traditional cohort, such as limited sample sizes and expensive resources.
The CIDACS Birth Cohort is housed at the Centre of Data and Knowledge Integration for Health (CIDACS), a unit of the Oswaldo Cruz Foundation in Bahia, Brazil. CIDACS also houses the 100 Million Brazilian Cohort. CIDACS works in the spectrum of data acquisition for linkage data from large Brazilian national databases, management, analysis and interpretation with ethical use and privacy issues.16
Ethical approval was obtained from the Federal University of Bahia’s Institute of Public Health Ethics Committee (CAAE registration number: 18022319.4.0000.5030).
Autoria: Enny Paixão, Luciana Cardim, Ila Rocha Falcão, Naiá Ortelan, Natanael de Jesus, Aline dos Santos Rocha, Samila Sena, Daniela Almeida, Dandara Ramos, Flávia Jôse Alves, Nívea Bispo da Silva, Rosemeire Leovigildo Fiaccone, Liam Smeeth, Liliana Cabral, Carlos Antonio de Souza Teles Santos, Maria Yury Ichihara, Mauricio Barreto, Rita de Cássia Ribeiro Silva, Maria da Glória Teixeira, Bethânia de Araújo Almeida.
Ano de publicação: 2020